氢氧气吸入对维持性血液透析患者微炎症状态和营养的改善效果分析. 赵慧; 王晨晖; 陈蓉; 秦晓鸥; 刘艳琴; 刘静娟; 高琳琳; 王保国 Objective To analyze the effect of hydrogen and oxygen inhalation on nutrition and microinflammation in maintenance hemodialysis (MHD) patients. Methods The stable MHD patients who underwent regular hemodialysis in the Hemodialysis Center of Beijing Taikang Yanyuan Rehabilitation Hospital were enrolled in this study. Every subject inhaled hydrogen and oxygen gases (3L/min, hydrogen: oxygen=2: 1) for 120 min during hemodialysis session for one month, and the subjects were observed and followed up for 6 months. Results A total of 37 patients were enrolled in this study, and 32 patients (25 males and 7 females) completed the trial. Their mean age was 64.4 ± 12.2 years, and mean dialysis age was 60.1 ± 49.5 months. In the first month after the start of treatment, serum albumin increased significantly compared to the baseline value (t=2.362, P=0.025). Serum albumin increased further in the second month (t=6.813, P＜0.001). Platelet/albumin (PAR) began to decline in the first month after treatment (t=0.252, P=0.802), and decreased further in the second month (t=2.906, P=0.007). Conclusion Inhalation of hydrogen and oxygen may improve nutrition and microinflammation status in MHD patients. 目的分析吸入氢气和氧气对维持性血液透析（MHD）患者营养状况及微炎症状态的影响。 方法 选取在北京泰康燕园康复医院血液透析中心接受规律血液透析的病情稳定的维持性血液透析患者。所有受试者在血液透析期间吸入氢氧混合气体（3 L/min，氢气:氧气=2:1），每次120 min，持续1个月，并对受试者进行6个月的观察随访。结果本研究共纳入37例患者，其中32例完成试验（男25例，女7例）；平均年龄（64.4±12.2）岁，平均透析龄（60.1±49.5）个月。治疗开始后第1个月，血清白蛋白较基线值显著升高（t=2.362，P=0.025）；第2个月血清白蛋白进一步升高（t=6.813，P＜0.001）。血小板/白蛋白比值（PAR）在治疗后第1个月开始下降（t=0.252，P=0.802），第2个月进一步降低（t=2.906，P=0.007）。 结论 吸入氢氧混合气可改善维持性血液透析患者的营养状况及微炎症状态。 临床研究注册信息：【ChiCTR2300077845】氢氧吸入对维持性血液透析患者微炎症状态、营养和生活质量的影响